In the long term the boys will need male sex hormone replacement. The introduction of testosterone pre-pubertally would need some age limitations. The defined onset of puberty in males occurs around the age of 11 years 6 months. As a result, a very low dose of testosterone could be given at around 10 years of age gradually increasing the dosage schedule.
This would in part mimic the changes that occur in normal boys. In adulthood depot preparations can be used as a gel, cream or sub-lingual preparation.
Testicular prostheses should be considered pre-pubertally to overcome psychological problems related to Anorchia.