The Rani is collecting a vast intergalactic menagerie in order to harness the power of a time tunnel and control galactic evolution. She has also interfered with the Doctor's timestream and trapped his various incarnations in a time loop. Two of his former selves are already prisoners in the time tunnel. It is up to the remaining five Doctors and their companions to stop the Rani and the numerous foes she has gathered to combat him.

This special Children in Need story saw the Doctor adventure with the Eastenders in Albert Square.